Effect of Cilnidipine on Left Ventricular Diastolic Function in Hypertensive Patients as Assessed by Pulsed Doppler Echocardiography and Pulsed Tissue Doppler Imaging
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of the present study was to examine the mechanisms of improvement in left ventricular (LV) diastolic function in hypertensive patients treated with cilnidipine, a new and unique calcium antagonist that has both L-type and N-type voltage-dependent calcium channel blocking actions, using pulsed Doppler echocardiography and pulsed tissue Doppler imaging. The study comprised 35 untreated patients with essential hypertension (19 men and 16 women; mean age 65±10 years). The peak early diastolic and atrial systolic transmitral flow velocities (E and A, respectively) and their ratio (E/A), and the peak early diastolic and atrial systolic motion velocities (Ew and Aw, respectively) of the LV posterior wall and their ratio (Ew/Aw) were determined in all patients before and after 1, 3 and 6 months on cilnidipine (10mg/day). One month: Systolic and diastolic blood pressures were significantly decreased. E and E/A were significantly increased, whereas there were no significant changes in Ew and Ew/Aw. Three months: Ew and Ew/Aw were significantly increased compared to those before and 1 month after cilindipine. Six months: E and E/A were significantly increased compared with before and 3 months after cilindipine, and Ew and Ew/Aw were significantly increased compared with before cilnidipine. Moreover, the LV mass index was significantly decreased compared to that before cilnidipine. In summary, changes in LV diastolic performance in patients with essential hypertension following cilnidipine treatment were biphasic with an initial increase in early diastolic transmitral flow velocity and a later increase in early diastolic LV wall motion velocity. The initial and later changes can be related to an acute change in afterload and a later improvement in LV relaxation.
- 社団法人日本循環器学会の論文
- 2001-03-20
著者
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Ito S
Department Of Digestive And Cardiovascular Medicine University Of Tokushima Graduate School
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Ito Susumu
徳島大学 大学院ヘルスバイオサイエンス研究部臓器病態治療医学
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Matsuoka Masako
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Onose Yukiko
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Oki Takashi
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Yamada Hirotsugu
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Manabe Kazuyo
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Kageji Yoshimi
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Yamamoto Takashi
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Tabata Tomotsugu
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Wakatsuki Tetsuzo
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Ito Susumu
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Tabata Tomotsugu
Department Of Digestive And Cardiovascular Medicine The University Of Tokushima Graduate School Of M
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Tabata Tomotsugu
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Oki Takashi
Cardiovascular Section, Higashi Tokushima National Hospital, National Hospital Organization
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Onose Yukiko
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Manabe Kazuyo
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Kageji Yoshimi
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Oki Takashi
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Tabata Tomotsugu
The Second Department Of Internal Medicine School Of Medicine University Of Tokushima
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Ito S
The Second Department Of Internal Medicine The University Of Tokushima School Of Medicine
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Yamamoto Takashi
Department Of Cardiology Tokushima Prefectural Central Hospital
-
Ito Susumu
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Tabata T
The Second Department of Internal Medicine School of Medicine,The University of Tokushima
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Yamada H
The Second Department of Internal Medicine School of Medicine,The University of Tokushima
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Onose Y
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Oki T
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Manabe K
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Kageji Y
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Matsuoka M
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Yamamoto T
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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Wakatsuki T
The Second Department of Internal Medicine, School of Medicine, The University of Tokushima
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