Effect of Autoxidation of Hydrogenated Castor Oil Containing 60 Oxyethlene Groups on Degradation of Miconazole

概要

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When 30 mg/ml aqueous hydrogenated castor oil consisting of 60 oxyethylene group (HCO-60) solutions were shaken under fluorescent light of about 500 lux in a water bath at 30℃ or 60℃, hydroperoxide, formaldehyde, and formic acid were formed. An aqueous solution containing 10 mg/ml miconazole (MCZ), 100 mg/ml HCO-60,and 1 mg/ml lactic acid was sealed in ampoules and stored at various temperatures for 8d. At 40℃ or above, the concentration of MCZ decreased accompanied by a decrease in pH and formaldehyde formation. However, in the presence of nitrogen, no degradation was observed. The degradation of MCZ was also observed in the presence of iron(II) ion and hydrogen peroxide. Degradation of MCZ and HCO-60 was prevented by the addition of hydroxy radical scavengers, especially potassium iodide and thiourea. These results indicate that hydroxy radicals generated by autoxidation of HCO-60 degraded MCZ.
公益社団法人日本薬学会の論文
1991-09-25