Synthesis and Antitumor Activities of Novel Benzoylphenylurea Derivatives

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概要

• 論文の詳細を見る

• Seventy novel benzoylphenylurea compounds were synthesized and their antitumor activities were examined in vivo against P388 leukemia. N-(2-Nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]ureas showed the highest antitumor activities when dosed intraperitoneally or orally. Their structure-activity relationships were examined with particular focus on the position and the variety of subsitituent on each aryl ring.

• 公益社団法人日本薬学会の論文
• 1991-09-25

著者

• 岡田 宏

  Agrochemical Research Laboratory Central Research Institute Ishihara Sangyo Kaisha Ltd.

• 山田 修逸

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 芳賀 隆弘

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 小柳 徹

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 岡田 宏

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 小柳 徹

  石原産業株式会社中央研究所

• 山田 修逸

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

• 小柳 徹

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

• 芳賀 隆弘

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

• Haga Takahiro

  Corporate Strategy-technology Ishihara Sangyo Kaisha Ltd.

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