Synthesis and Antipancreatitis Activities of Novel N-(2-Sulfonylamino-5-trifluoromethyl-3-pyridyl)carboxamide Derivatives as Phospholipase A_2 Inhibitors

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概要

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• Novel N-(2-sulfonylamino-5-trifluoromethyl-3-pyridyl)carboxamide derivatives have been prepared and evaluated as phospholipase A_2 (PLA_2) inhibitors. Among these compounds, IS-741 (sodium salt of 1j), which showed the highest and the most stable therapeutic effect on acute hemorrhagic pancreatitis induced by the closed duodenal loop method in rats, was selected as a candidate for further development.

• 1995-10-15

著者

• 重原 格

  Technical Research Institute Ishihara Sangyo Kaisha Ltd.

• 木村 博彦

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

• 芳賀 隆弘

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

• 芳賀 隆弘

  Corporate Strategy-technology Ishihara Sangyo Kaisha Ltd.

• 杉 秀男

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

• 四谷 収一

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

• 湯木 俊次

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

• Haga Takahiro

  Corporate Strategy-technology Ishihara Sangyo Kaisha Ltd.

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• Synthesis and Antipancreatitis Activities of Novel N-(2-Sulfonylamino-5-trifluoromethyl-3-pyridyl)carboxamide Derivatives as Phospholipase A_2 Inhibitors
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