Synthesis and Antitmor Activities of Prodrugs of Benzoylphenylureas

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概要

• 論文の詳細を見る

• Various benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. All of the prodrugs were soluble in most organic solvents and showed good antitumor activities against P388 leukemia cells in mice when dosed intraperitoneally or orally.

• 公益社団法人日本薬学会の論文
• 1994-01-15

著者

• 岡田 宏

  Agrochemical Research Laboratory Central Research Institute Ishihara Sangyo Kaisha Ltd.

• 山田 修逸

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 小柳 徹

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 岡田 宏

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 山田 修逸

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

• 小柳 徹

  Central Research Institute Ishihara Sangyo Kaisha Ltd.

関連論文

• Improved Oral Absorption of a Poorly Water-Soluble Drug, HO-221,by Wet-Bead Milling Producing Particles in Submicron Region
• チオメチル基を有するクロロニコチニル系化合物の殺虫活性と選択毒性
• N-ホスフィノイル置換複素環化合物の合成と殺虫活性
• Synthesis and Antitmor Activities of Prodrugs of Benzoylphenylureas
• Synthesis and Antitumor Activities of Novel Benzoylphenylurea Derivatives
• アルキル化 N-ベンゾイル-N′-フェニルウレア誘導体の合成と殺虫活性及び水棲動物に対する毒性

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