Synthesis of Peptides Related to Immunoglobulin E (IgE) and the Examination of Their Pharmacological Activity
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概要
- 論文の詳細を見る
Five kinds of oligopeptides H-Asp-Ser-Asp-OH (1), H-Asp-Gly-Lys-OH (2), H-Ser-Asp-Gly-Lys-OH (3), H-Asp-Ser-Asp-Gly-Lys-OH (4), and H-Ala-Asp-Ser-Asp-Gly-Lys-OH (5) related to immunoglobulin E (IgE) were synthesized by the conventional solution method with the objective of obtaining a new type of antiallergic agent. Their pharmacological activity was examined by measuring the inhibition of the production of IgE and relaxation of the smooth muscle contraction of rabbit aorta. H-Ala-Asp-Ser-Asp-Gly-Lys-OH (5) displayed potent inhibition against the production of IgE antibody (69.6%) and relaxation against the contraction of rabbit aorta.
- 公益社団法人日本薬学会の論文
- 1990-09-25
著者
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大田 憲哉
Hitachi Chemical Co. Ltd. Ibaraki Research Laboratory
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野口 桂一
Hitachi Chemical Co., Ltd., Ibaraki Research Laboratory
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松尾 克郎
Hitachi Chemical Co., Ltd., Ibaraki Research Laboratory
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野口 桂一
日立化成工業
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松尾 克郎
Hitachi Chemical Co. Ltd. Ibaraki Research Laboratory
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