A Biologically Active Insulin Analogue with Modification in the A^2 Position. [2-Valine-A] Sheep Insulin

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概要

• 論文の詳細を見る

• The synthesis and biological evaluation of [2-Valine-A] insulin ([Val^2-A]insulin) is reported. In this insulin, the isoleucine residue in position A^2,invariant in the majority of mammalian insulins, is substituted by valine. The same substitution, along with four others, occurs naturally in the insulin produced by the owl monkey. Owl monkey insulin exhibits ca. 20% of the activity of porcine insulin in in vitro insulin assays using human cells in culture.[Val^2-A]insulin displays 20-22% of the activity of bovine insulin in in vitro insulin assays using rat liver plasma membranes or isolated rat adipocytes. We suggest that the substitution of valine for isoleucine at position A^2 is responsible for all or most of the diminution in potency of owl monkey insulin relative to porcine insulin. The data are discussed with regard to previous findings with insulin analogues in which isolecine A^2 was replaced with norleucine, glycine and alanine.

• 公益社団法人日本薬学会の論文
• 1989-03-25

著者

• 大田 憲哉

  Hitachi Chemical Co. Ltd. Ibaraki Research Laboratory

• 大田 憲哉

  Department of Biochemistry, Mount Sinai School of Medicine of the City University of New York

• BURKE G.Thompson

  Department of Biochemistry, Mount Sinai School of Medicine of the City University of New York

• KATSOYANNIS Panayotis

  Department of Biochemistry, Mount Sinai School of Medicine of the City University of New York

• Burke G.thompson

  Department Of Biochemistry Mount Sinai School Of Medicine Of The City University Of New York

• Katsoyannis Panayotis

  Department Of Biochemistry Mount Sinai School Of Medicine Of The City University Of New York

関連論文

• Amino Acids and Peptides. XIII. : Synthesis of a Nonacosapeptide Corresponding to the N-Terminal Sequence 1-29 (β-Fragment) of Human Liver Metallothionein II (hMT II) and Its Heavy Metal-Binding Properties
• Amino Acids and Peptides. I. Synthesis of a Model Peptide related to Iron-Sulfur Protein
• Synthesis of Peptides Related to Immunoglobulin E (IgE) and the Examination of Their Pharmacological Activity
• A Biologically Active Insulin Analogue with Modification in the A^2 Position. [2-Valine-A] Sheep Insulin
• Amino Acids and Peptides. IX. Synthesis of Cysteine-Containing Peptide Fragments Related to Human Hepatic Metallothionein II (hMT II) and Determination of Their Heavy Metal-Binding Properties
• Amino Acids and Peptides. VIII. Synthesis of a Hexacosapeptide corresponding to the C-Terminal Sequence 36-61 of Human Metallothionein II (hMT II) and Determination of Its Heavy Metal Binding Activity
• Amino Acids and Peptides. VII. Synthesis of Methionine-Enkephalin using Transfer Hydrogenation

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