INHIBITION OF ANGIOGENESIS BY BLEOMYCIN AND ITS COPPER COMPLEX

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概要

• 論文の詳細を見る

• The effects of bleomycin (BLM) and its copper complex on embryonic angiogenesis were studied in the chorioallantoic membranes of 4.5-day-old chick embryos. Copper-free BLM inhibited embryonic angiogenesis in a dose-dependent manner, with activity detectable at 1 ng/egg and maximal at 1000 ng/egg. Also, treatment with copper-BLM complex dose-dependently caused inhibition of embryonic angiogenesis in a lower dose range. Since tumor growth is believed to depend on angiogenesis, the present results may indicate that the antiangiogenic activity of BLM is, at least in part, implicated in the antitumor activity of the drug.

• 公益社団法人日本薬学会の論文
• 1990-06-25

著者

• 片山 敬

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 島村 真里子

  都臨床研

• 島村 真里子

  Division Of Cancer Therapeutics The Tokyo Metropolitan Institute Of Medical Science

• 中村 治

  Division Of Neurosurgery The Tokyo Metropolitan Komagome Hospital

• 及川 勉

  (財)東京都臨床医学総合研究所化学療法研究部門

• 及川 勉

  Division of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science

• 廣谷 賢志

  Division of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science

• 小笠原 宏幸

  Division of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science

• 芦野 洋美

  Division of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science

• 岩口 孝雄

  Division of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science

• 岩口 孝雄

  Division Of Cancer Therapeutics The Tokyo Metropolitan Institute Of Medical Science

• 廣谷 賢志

  Division Of Cancer Therapeutics The Tokyo Metropolitan Institute Of Medical Science:faculty Of Pharm

• 小笠原 宏幸

  Department Of Cancer Therapeutics The Tokyo Metropolitan Institute Of Medical Science:(present Addre

• 芦野 洋美

  Division Of Cancer Therapeutics The Tokyo Metropolitan Institute Of Medical Science

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