DEPUDECIN, A MICROBIAL METABOLITE CONTAINING TWO EPOXIDE GROUPS, EXHIBITS ANTI-ANGIOGENIC ACTIVITY IN VIVO

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概要

• 論文の詳細を見る

• Depudecin, a microbial metabolite containing two epoxide groups, was tested for its anti-angiogenic activity in an in vivo assay system involving the chorioallantoic membrane of growing chick embryo. The microbial metabolite inhibited embryonic angiogenesis in a dose-dependent manner with an ID_<50> of 320ng (1.5 nmol) per egg. It also affected the growth of vascular endothelial cells, a key event in the process of angiogenesis in vivo. These results suggest that depudecin could be promising as an anti-angiogenic agent and that its anti-angiogenic action involves an inhibitory effect on vascular endothelial cell growth.

• 公益社団法人日本薬学会の論文
• 1995-09-15

著者

• 及川 勉

  Department of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science

• 小野沢 千津子

  理研

• 佐々木 美幸

  Department Of Cancer Therapeutics The Tokyo Metropolitan Institute Of Medical Science (rinshoken)

• 及川 勉

  (財)東京都臨床医学総合研究所化学療法研究部門

• 小野沢 千津子

  Department of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science (Rinshoken)

• 猪瀬 雅世

  Department of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science (Rinshoken)

• 猪瀬 雅世

  Department Of Cancer Therapeutics The Tokyo Metropolitan Institute Of Medical Science (rinshoken)

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