THREE ISOFORMS OF PLATELET-DERIVED GROWTH FACTORS ALL HAVE THE CAPABILITY TO INDUCE ANGIOGENESIS IN VIVO
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概要
- 論文の詳細を見る
Three isoforms of platelet-derived growth factors (PDGFs) composing of AA, AB and BB chains all exhibited angiogenic activity in a dose-dependent manner in an in vivo assay system involving the chorioallantoic membrane of chick embryo. The order of potency was BB>AB=AA. They, however, failed to stimulate proliferation of vascular endothelial cells, suggesting that their effects are indirect. These data suggest the possibility that three PDGF isoforms are indirect angiogenic factors.
- 公益社団法人日本薬学会の論文
- 1994-12-15
著者
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及川 勉
Department of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science
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室田 誠逸
Tokyo Metropolitan Institute of Gerontology
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小野沢 千津子
理研
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及川 勉
(財)東京都臨床医学総合研究所化学療法研究部門
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小野沢 千津子
Department of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science (Rinshoken)
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坂口 美里
Department of Cancer Therapeutics, The Tokyo Metropolitan Institute of Medical Science
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森田 育男
Tokyo Medical and Dental University
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坂口 美里
Department Of Cancer Therapeutics The Tokyo Metropolitan Institute Of Medical Science
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