Anticonvulsant Activity of 3-Oxo-5-substituted Benzylidene-6-methyl-(4H)-2-pyridazinylacetamides and 2-Pyridazinylacetylhydrazides

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概要

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• A series of 3-oxo-5-substituted-benzylidene-6-methyl-(4H)-2-pyridazinylacetamides and 2-pyridazynylacetylhydrazides were synthesized and evaluated for anticonvulsant activity against electrically and chemically induced seizures.In the maximal electroshock-induced seizures test, most of the derivatives showed an anticonvulsant effect better than that of sodium valproate, a commonly used anticonvulsant drug.At 100 mg/kg orally, compounds 5a and 5b respectively protected 50 and 60% of the mice against pentylentetrazole-induced seizures. In addition, these two derivatives showed significant anticonvulsant properties at doses that did not produce ataxia or sedation. The title compounds were also tested for their ability to antagonize convulsions induced by bicuculline and strychnine. Their effect on tremors induced by oxotremorine in mice was also evaluated.

• 公益社団法人日本薬学会の論文
• 1990-11-25

著者

• RUBAT Catherine

  Laboratoire de Pharmacologie Faculte des Sciences Pharmaceutiques, Universite Francois Rabelais

• BASTIDE Pierre

  Laboratoire de Pharmacologie et de Pharmacie Clinique

• TRONCHE Pierre

  Groupe de Recherches en Pharmacochimie, Laboratoire de Chimie Therapeutique

• BASTIDE JEANINE

  Laboratoire de Pharmacodynamie

• Bastide P

  Ufr Pharmacie Clermont‐ferrand Fra

• Tronche P

  Fac. Pharmacie Clermont‐ferrand Fra

• Tronche Pierre

  Groupe De Recherche En Pharmacochimie Faculte De Pharmacie

• Coudert Pascal

  Groupe De Recherche En Pharmacochimie Laboratoire De Chimie Therapeutique Faculte Des Sciences Pharm

• Bastide Pierre

  Laboratoire De Chimie Biologique Et Pharmacodynamie

• Bastide Jeanine

  Laboratoire De Pharmacologie Et De Pharmacie Clinique:faculte De Pharmacie Universite De Clermont-fe

• Rubat C

  Laboratoire De Pharmacologie Faculte Des Sciences Pharmaceutiques Universite Francois Rabelais

• REFOUVELET Bernard

  Groupe de Recherches en Pharmacochimie, Laboratoire de Chimie Therapeutique

• Refouvelet Bernard

  Groupe De Recherches En Pharmacochimie Laboratoire De Chimie Therapeutique:faculte De Pharmacie Univ

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• Synthesis and Pharmacological Evaluation of N-Substituted 4,6-Diaryl-3-pyridazinones as Analgesic, Antiinflammatory and Antipyretic Agents
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