Antidepressant Activity of New 3-Amino-5-disubstituted Benzylidene-6-methyl-(4H)-pyridazine Derivatives

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概要

• 論文の詳細を見る

• By the reaction of various amines with 3-chloropyridazines, several minaprine analogues were prepared. Most of them exhibited significant antidepressant activity. Compound 2a antagonizes reserpine action and neuroleptic-induced catalepsy in a dose-dependent manner.

• 公益社団法人日本薬学会の論文
• 1988-12-25

著者

• RUBAT Catherine

  Laboratoire de Pharmacologie Faculte des Sciences Pharmaceutiques, Universite Francois Rabelais

• BASTIDE Pierre

  Laboratoire de Pharmacologie et de Pharmacie Clinique

• TRONCHE Pierre

  Groupe de Recherches en Pharmacochimie, Laboratoire de Chimie Therapeutique

• COUDERT PASCAL

  Laboratoire de Chimie Therapeutique

• Bastide P

  Ufr Pharmacie Clermont‐ferrand Fra

• Tronche P

  Fac. Pharmacie Clermont‐ferrand Fra

• Coudert Pascal

  Groupe De Recherche En Pharmacochimie Laboratoire De Chimie Therapeutique Faculte Des Sciences Pharm

• Bastide Pierre

  Laboratoire De Chimie Biologique Et Pharmacodynamie

• Rubat C

  Laboratoire De Pharmacologie Faculte Des Sciences Pharmaceutiques Universite Francois Rabelais

• TRONCHE PIERRE

  Laboratoire de Chimie Therapeutique

関連論文

• Synthesis and Pharmacological Evaluation in Mice of New Non-classical Antinociceptive Agents, 5-(4-Arylpiperazin-1-yl)-4-benzyl-1,2-oxazin-6-ones
• Synthesis and Trazodone-like Analgesic Activity of 4-Phenyl-6-aryl-2-[3-(4-arylpiperazin-1-yl)propyl]pyridazin-3-ones
• Effect on Free Radical Processes of Some Ascorbic Acid Analogues
• Synthesis and Aldose Reductase Inhibitory Activity of Triazine Derivatives Possessing Acetic Acid Group
• Synthesis and Analgesic Effect of N-Substituted 5-Arylidene-6-methyl-3-(4H)-pyridazinones
• Studies on Immunostimulating Derivatives : Synthesis of Some Pyrrolo[1,2-c]pyrimidines
• Procyanidins from Tormentil : Fractionation and Study of the Anti-radical Activity towards Superoxide Anion
• Procyanidins from the Roots of Fragaria vesca : Characterization and Pharmacological Approach
• Anticonvulsant Activity of 3-Oxo-5-substituted Benzylidene-6-methyl-(4H)-2-pyridazinylacetamides and 2-Pyridazinylacetylhydrazides
• Synthesis and Pharmacological Evaluation of N-Substituted 4,6-Diaryl-3-pyridazinones as Analgesic, Antiinflammatory and Antipyretic Agents
• Antidepressant Activity of New 3-Amino-5-disubstituted Benzylidene-6-methyl-(4H)-pyridazine Derivatives

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