Synthesis and Pharmacological Evaluation of N-Substituted 4,6-Diaryl-3-pyridazinones as Analgesic, Antiinflammatory and Antipyretic Agents

スポンサーリンク

概要

• 論文の詳細を見る

• The synthesis and the pharmacological evaluation of 19 new 4,6-diaryl-3-pyridazinones are reported. All compounds were screened for analgesic, antiinflammatory and antipyretic activities. Introduction of an arylpiperazinomethyl moiety in the 2-position of the pyridazinone ring resulted in the most potent activities. Compounds 2a, 2b, 2h and 2i exhibited a higher analgesic activity than did aspirin or noramidopyrine in the hot plate test.

• 公益社団法人日本薬学会の論文
• 1989-10-25

著者

• RUBAT Catherine

  Laboratoire de Pharmacologie Faculte des Sciences Pharmaceutiques, Universite Francois Rabelais

• BASTIDE Pierre

  Laboratoire de Pharmacologie et de Pharmacie Clinique

• TRONCHE Pierre

  Groupe de Recherches en Pharmacochimie, Laboratoire de Chimie Therapeutique

• BASTIDE JEANINE

  Laboratoire de Pharmacodynamie

• Bastide P

  Ufr Pharmacie Clermont‐ferrand Fra

• Tronche P

  Fac. Pharmacie Clermont‐ferrand Fra

• Tronche Pierre

  Groupe De Recherche En Pharmacochimie Faculte De Pharmacie

• Coudert Pascal

  Groupe De Recherche En Pharmacochimie Laboratoire De Chimie Therapeutique Faculte Des Sciences Pharm

• Bastide Pierre

  Laboratoire De Chimie Biologique Et Pharmacodynamie

• Bastide Jeanine

  Laboratoire De Pharmacologie Et De Pharmacie Clinique:faculte De Pharmacie Universite De Clermont-fe

• Rubat C

  Laboratoire De Pharmacologie Faculte Des Sciences Pharmaceutiques Universite Francois Rabelais

• PRIVAT Anne-Marie

  Laboratoire de Pharmacologie et de Pharmacie Clinique

• Privat Anne-marie

  Laboratoire De Pharmacologie Et De Pharmacie Clinique:faculte De Pharmacie Universite De Clermont-fe

関連論文

• Synthesis and Pharmacological Evaluation in Mice of New Non-classical Antinociceptive Agents, 5-(4-Arylpiperazin-1-yl)-4-benzyl-1,2-oxazin-6-ones
• Synthesis and Trazodone-like Analgesic Activity of 4-Phenyl-6-aryl-2-[3-(4-arylpiperazin-1-yl)propyl]pyridazin-3-ones
• Effect on Free Radical Processes of Some Ascorbic Acid Analogues
• Synthesis and Aldose Reductase Inhibitory Activity of Triazine Derivatives Possessing Acetic Acid Group
• Synthesis and Analgesic Effect of N-Substituted 5-Arylidene-6-methyl-3-(4H)-pyridazinones
• Studies on Immunostimulating Derivatives : Synthesis of Some Pyrrolo[1,2-c]pyrimidines
• Procyanidins from Tormentil : Fractionation and Study of the Anti-radical Activity towards Superoxide Anion
• Procyanidins from the Roots of Fragaria vesca : Characterization and Pharmacological Approach
• Immunomodulatory Agents : Dioxothiadiazabicyclo[3.3.0]octanes and Their 2-Spiro Derivatives
• Anticonvulsant Activity of 3-Oxo-5-substituted Benzylidene-6-methyl-(4H)-2-pyridazinylacetamides and 2-Pyridazinylacetylhydrazides
• Synthesis and Pharmacological Evaluation of N-Substituted 4,6-Diaryl-3-pyridazinones as Analgesic, Antiinflammatory and Antipyretic Agents
• Antidepressant Activity of New 3-Amino-5-disubstituted Benzylidene-6-methyl-(4H)-pyridazine Derivatives

もっと見る 閉じる

スポンサーリンク