Synthesis and Analgesic Effect of N-Substituted 5-Arylidene-6-methyl-3-(4H)-pyridazinones

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概要

• 論文の詳細を見る

• Two methods of N-substitution were applied to 5-arylidene-6-methyl-3-(4H)-pyridazinones. The resulting derivatives were tested in order to determine the area of pharmacological activity. Most compounds exhibited a dose-dependent analgesic activity. Introduction of a benzoyl substituent in the 2-position of the pyridazinone ring 2j induced the most potent activity.

• 公益社団法人日本薬学会の論文
• 1988-04-25

著者

• Couquelet J

  Groupe De Recherche En Pharmacochimie Laboratoire De Chimie Therapeutique Faculte Des Sciences Pharm

• RUBAT Catherine

  Laboratoire de Pharmacologie Faculte des Sciences Pharmaceutiques, Universite Francois Rabelais

• BASTIDE Pierre

  Laboratoire de Pharmacologie et de Pharmacie Clinique

• COUDERT PASCAL

  Laboratoire de Chimie Therapeutique

• COUQUELET JACQUES

  Laboratoire de Chimie Therapeutique

• BASTIDE JEANINE

  Laboratoire de Pharmacodynamie

• Bastide P

  Ufr Pharmacie Clermont‐ferrand Fra

• Coudert Pascal

  Groupe De Recherche En Pharmacochimie Laboratoire De Chimie Therapeutique Faculte Des Sciences Pharm

• Bastide Pierre

  Laboratoire De Chimie Biologique Et Pharmacodynamie

• Bastide Jeanine

  Laboratoire De Pharmacologie Et De Pharmacie Clinique:faculte De Pharmacie Universite De Clermont-fe

• Rubat C

  Laboratoire De Pharmacologie Faculte Des Sciences Pharmaceutiques Universite Francois Rabelais

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• Synthesis and Analgesic Effect of N-Substituted 5-Arylidene-6-methyl-3-(4H)-pyridazinones
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• Synthesis and Pharmacological Evaluation of N-Substituted 4,6-Diaryl-3-pyridazinones as Analgesic, Antiinflammatory and Antipyretic Agents
• Antidepressant Activity of New 3-Amino-5-disubstituted Benzylidene-6-methyl-(4H)-pyridazine Derivatives

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