Effect of Crystallinity on the Percutaneous Absorption of Corticosteroid. II. Chemical Activity and Biological Activity
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概要
- 論文の詳細を見る
The effects of the crystallinity of hydrocortisone acetate and betamethasone dipropionate on their percutaneous absorption were examined. The potency of vasoconstriction of the amorphous corticosteroid was higher than that of the crystalline form and lower than that of the dissolved form. The amorphous state of hydrocortisone acetate in white petrolatum ointment was stabilized by coprecipitation of the drug with polyvinylpyrrolidone. The chemical activity was correlated with the biological activity.
- 公益社団法人日本薬学会の論文
- 1985-05-25
著者
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広田 貞雄
Pharmaceutical Formulation Research Center Research Institute Daiichi Pharmaceutical Co. Ltd. :(pres
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森田 正美
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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森田 正美
Pharmaceutical Formulation Research Center, Research Institute, Daiichi Seiyaku Co., Ltd.
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