Estimation of the Shelf Life of a Drug in Its Solid State. II. A Proposition for a New Kinetical Equation of Gas-Solid Reactions for Pharmaceutical Solids
スポンサーリンク
概要
- 論文の詳細を見る
A new kinetical equation for a gas-solid reaction which is convenient for use in predicting the degradation of a pharmaceutical solid is derived, and a procedure of analyzing accelerated storage data is proposed. The procedure is applied to the air oxidation degradation of ascorbic acid in a mannitol conglomerate. The result of the analysis was consistent with that obtained by Lacey's procedure. With the proposed procedure, operational difficulties met in Lacey's procedure were overcome. The temperature dependence of diffusivity is found to be 56 kcal/mole, with an activation energy for the chemical reaction of 26 kcal/mole. The rate constant for the chemical reaction at 25° is estimated to be 3.3×10^<-6> hr^<-1>, a value which is consistent with the results of Tardif, which were obtained from a different point of view.
- 公益社団法人日本薬学会の論文
- 1968-10-25
著者
関連論文
- Effect of Crystallinity on the Percutaneous Absorption of Corticosteroid. II. Chemical Activity and Biological Activity
- Effect of Crystallinity on the Percutaneous Absorption of Corticosteroid. I. Determination of the Degree of Crystallinity of Hydrocortisone Acetate in Ground Mixtures with Crystalline Cellulose
- Estimation of the Degree of Crystallinity and the Disorder Parameter in a Drug by an X-Ray Diffraction Method with a Single Sample
- A Spray-Drying Method for Mass Production of Liposomes
- Possibility of Heat Sterilization of Liposomes
- Texture Study on Optimum Formulation of Molded Poultices
- W/O型抗炎症エマルジョン製剤のコロイド化学的安定性に関する誘電的研究
- Effects of Particle Size and Stabilizing Agents upon Dielectric Properties of Water-in-Oil Type Emulsions
- Dielectric Studies of Emulsions of Polyol in Hydrophobic Colloidal Silica-Oil Gel
- Dielectric Studies on Emulsion of Aqueous Agarose Gel in Hydrophobic Colloidal Silica-Oil Gel
- Fused 1,3-Oxazine Derivatives. Synthesis of 2H-1,3-Oxazino [5,6-b]-quinoxaline-2,4 (3H)-diones (1-Oxaalloxazines), 2H-1,3-Oxazino-[6,5-b] quinoline-2,4 (3H)-diones (5-Deaza-1-oxaalloxazines), and 2H-Pyrido [3,2-e]-1,3-oxazine-2,4 (3H)-diones
- Dielectric Studies on Emulsion of Water in Hydrophobic Colloidal Silica-Oil Gel. II
- Dielectric Studies on Emulsion of Water in Hydrophobic Colloidal Silica-Oil Gel
- Stability of Ascorbic Acid in Fused System Containing Ascorbic Acid and Mannitol
- Estimation of the Shelf Life of a Drug in Its Solid State. II. A Proposition for a New Kinetical Equation of Gas-Solid Reactions for Pharmaceutical Solids
- Estimation of the Shelf Life of a Drug in Its Solid State. I. An Application of Lacey's Theory to a Kinetic Analysis of an Air Oxidation of Ascorbic Acid in Its Solid State