Studies on the Synthesis of New Antimicrobials. II. Syntheses of 3-(5-Nitro-2-thienyl) acrylic Acid Derivatives and their Some Antibacterial Activities.
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概要
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3-(5-Nitro-2-thienyl) acrylic acid was synthesized in good yield by direct nitration of 3-(2-thienyl) acrylic acid obtained from 2-thiophenecarboxaldehyde without proceeding through 5-nitro-2-thiophenecarboxaldehyde diacetate. By condensation of the acid with various amines, alcohols or phenols, its amide and ester derivatives were prepared. 2-Bromo-3-(5-nitro-2-thienyl) acrylic acid esters were also obtained by bromination of the corresponding esters. Antibacterial activity of these compounds was tested on some bacteria in vitro.
- 1962-12-25
著者
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木村 隆一
Reseach Institute For Production Development
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木村 隆一
Scientific Research Institute for Practical Life and Chemical Research Institute, University of Kyot
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藪内 隆弘
Scientific Research Institute for Practical Life and Chemical Research Institute, University of Kyot
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久木 正勝
Scientific Research Institute for Practical Life, University of Kyoto
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久木 正勝
Reseach Institute For Production Development
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藪内 隆弘
Reseach Institute For Production Development
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