Studies on Thiophene Derivatives. II. Optical Resolution of 3-Piperidino-1,1-di (2-thienyl)-1-butene.
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概要
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Optical resolution of 3-piperidino-1,1-di (2-thienyl)-1-butene hydrochloride and hydrobromide, which had interesting pharmacological properties, was carried out by the preferential recrystallization method, because these could not be resolved by a method for diastereomers. Thus, specific rotation of these isomers was found to be [α]^<31.5>_D ±117.8° in ethanol for isomers of hydrochloride and [α]^<13>_D ±127.4° in chloroform for those of hydrobromide. Moreover, it was recognized that the racemic modifications of these salts were racemic mixtures and not racemic compounds, by the investigation of the melting point-composition diagrams and infrared absorption spectra.
- 1959-03-20
著者
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木村 隆一
Reseach Institute For Production Development
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木村 隆一
Scientific Research Institute for Practical Life and Chemical Research Institute, University of Kyot
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藪内 隆弘
Scientific Research Institute for Practical Life and Chemical Research Institute, University of Kyot
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藪内 隆弘
Reseach Institute For Production Development
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