Studies on Thiophene Derivatives. I. Syntheses of 2-Amino-1,1-di (2-thienyl) alkanols.

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概要

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• It was found that 3-piperidino-1,1-di (2-thienyl) butene prepared by Adamson possessed an antitussive action. The compound has one amino group at the 3-position, and one double bond between 1 and 2. However, ephedrine used as an antitussive for a long time has one amino group at 2-position and a hydroxyl group at 1-position. Therefore, 2-amino-1,1-di (2-thienyl) propanols and 2-amino-1,1-di (2-thienyl)-ethanols which have one amino group at 2-position and hydroxyl group at 1-position were synthesized, in order to investigate the structure-activity relationship of the antitussive. The compounds were synthesized by the condensation of 1-aminoalkane-1-carboxylic acid esters and thiophene (the lithium method).

• 公益社団法人日本薬学会の論文
• 1958-04-20

著者

• 木村 隆一

  Reseach Institute For Production Development

• 田村 泰隆

  Scientific Research Institute For Practical Life And Chemical Research Institute University Of Kyoto

• 木村 隆一

  Scientific Research Institute for Practical Life and Chemical Research Institute, University of Kyot

• 薮内 隆弘

  Scientific Research Institute for Practical Life, University of Kyoto

• 薮内 隆弘

  Scientific Research Institute For Practical Life University Of Kyoto

関連論文

• Studies on Thiophene Derivatives. IV. Syntheses of 2-Aminoethyl 3,3-Diaryl-3-hydroxypropanoates and 3,3-Diaryl-2-prpenoates.
• Studies on Thiophene Derivatives. I. Syntheses of 2-Amino-1,1-di (2-thienyl) alkanols.
• Studies on the Synthesis of New Antimicrobials. I. Synthesis of 2,5-Dichloroaniline Derivatives and their Some Antibacterial Activities.
• Synthesis of New Antimicrobials. V. Synthesis of Alkylenebis-(thiosemicarbazides) and Their Related Compounds
• Synthesis of New Antimicrobials. IV. Synthesis of Alkylenebis-(thiourea) Derivatives and Their Related Compounds
• Synthesis of New Antimicrobials. III. Synthesis of Chlorine-substituted 4-Thiocyanatoaniline and 2-Amino-6-chlorobenzothiazole Derivatives
• Studies on the Synthesis of New Antimicrobials. II. Syntheses of 3-(5-Nitro-2-thienyl) acrylic Acid Derivatives and their Some Antibacterial Activities.
• Studies on Thiophene Derivatives. III. Clinical Application of 3-Piperidino-1,1-di (2-thienyl)-1-butene as a New Antitussive.
• Studies on Thiophene Derivatives. II. Optical Resolution of 3-Piperidino-1,1-di (2-thienyl)-1-butene.

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