Activation of Hyaluronidase by Spermine and Related Diamines.
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概要
- 論文の詳細を見る
Spermine was found to be the powerful activator of bovine testicular hyaluronidase at 10^<-4>M concentration. The enzyme activity was determined either in vitro by viscometric and reductometric methods or in vivo by intracutaneous diffusion method. Oxidation of spermine oxidase originating in goat serum resulted in the loss of activation of the enzyme activity. Several amines, especially polymethylenediamines related to spermine, were also found to exhibit similar activating effect on hyaluronidase, although the effect is less than that of spermine. The activity of these amines at 10^<-3>M concentration decreases in the following order : Spermine, spermidine, trimethylenediamine, histamine, hexamethylenediamine, putrescine, cadaverine and ethylenediamine.
- 公益社団法人日本薬学会の論文
- 1959-02-10
著者
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宮木 高明
Research Institute for Chemobiodynamics, University of Chiba
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宮木 高明
Research Institute For Chemobiodynamics University Of Chiba
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宮木 高明
Faculty of Pharmacy University of Chiba
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和田 忠男
Central Research Laboratories Sankyo Co. Ltd.
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持田 勇
Faculty of Pharmacy, University of Chiba
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和田 忠男
Faculty of Pharmacy, University of Chiba
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工藤 武子
Faculty of Pharmacy, University of Chiba
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持田 勇
Faculty Of Pharmacy University Of Chiba
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工藤 武子
Faculty Of Pharmacy University Of Chiba
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