カルボン酸アルカミンエステルアンモニウム塩の合成研究(第2報)
スポンサーリンク
概要
- 論文の詳細を見る
1) β-Haloethyl esters of carboxylic acid was formed by the reaction of a carboxylic acid with ethylenehalohydrin in carbon tetrachloride, with a few drops of sulfuric acid as a catalyst. The β-haloethyl carboxylates thereby obtained were reacted with secondary or tertiary amines and several kinds of aminoalkyl carboxylate derivatives possessing antispasmodic action were prepared. 2) In the esterification of benzilic acid with ethylenehalohydrin, only the esterification occurs when the amount of sulfuric acid catalyst is small but in the presence of a large amount of the acid, concurrent etherification was found to occur. This was utilized in preparation of β-bromoethyl O-(β'-bromoethyl) benzilate (XIV) which was reacted with a secondary or tertiary amine and some novel derivatives of aminoalkyl carboxylate were obtained. 3) Application of tertiary amines with branched alkyl chain, such as diisopropylmethylamine, to β-bromoethyl diphenylacetate (IV) failed to cause the anticipated quaternization.
- 社団法人日本薬学会の論文
- 1955-12-20
著者
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吉田 茂
Takamine Research Laboratory, Sankyo Co., Ltd.
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吉田 茂
Takamine Research Laboratory Sankyo Co. Ltd.
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岩重 忠博
Takamine Research Laboratory, Sankyo Co. Ltd.
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岩重 忠博
Takamine Research Laboratory Sankyo Co. Ltd.
関連論文
- Studies on the Allied Compounds of Vitamin B_1. XXIII. Synthesis of N-Acyl-O, S-dibenzoylthiamines.
- Studies on Allied Compounds of Vitamin B_1. XXI. The Structure of Dihydrothiamine. (2).
- Studies on the Allied Compounds of Vitamin B_1. XX. The Structure of Dihydrothiamine. (1)
- Infrared Spectra of Benzoyl Halides and their Substituted Derivatives.
- On the CH Out-of-plane Vibrations and Extra Bands of Benzoic Acid, Benzoic Acid Esters, Benzoyl Chloride, and their para-Substituted Derivatives
- Infrared Spectra of Pyrazine-and Pyridine-carboxylic Acid and Their Derivatives.
- Studies on the Allied Compounds of Vitamin B_1. XXII. Acylation of Thiothiamine and Its Derivatives.
- カルボン酸アルカミンエステルアンモニウム塩の合成研究(第2報)
- ビタミンB_1関係化合物の研究(第17報) : N-置換Thiocarbamateの構造
- Studies on Acetylenic Compounds. XXIX. A New Method for Synthesis of DL-Ribose.
- Syntheses of 2-Hydroxymethylnicotinic Acid Lactone, 2-Hydroxymethylpyridine-3-acetic Acid Lactone, and Some of their Derivatives
- Gas Liquid Partition Chromatography of 2,3-An-hydro-D-ribofuranoside and 2,3-Anhydro-D-lyxofuranoside.
- Studies on Acetylenic Compounds. XVIII. Total Synthesis of dl-Lyxose and dl-Xylose.
- Studies on Acetylenic Compounds. XVII. Total Synthesis of dl-Ribose and dl-Arabinose.