Effects of Charge Density on Drug Permeability through Alginate Gel Membranes

概要

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Preparation methods for the alginate (Alg) gel membranes were deceloped and characterized. Three kinds of Alg gel membrane (mannuronate/guluronate ratio (M/G ratio)=1.00,0.43,and 0.19) were prepared by a casting method, and the effects of M/G on characteristics such as transmittancy, viscoelasticity, effective charge densities, and drug permeability were investigated. The water content and membrane thickness of the Alg gel membranes were not affected by the M/G ratio, however, transmittancy and viscoelasticity were found to be significantly affected by them. Charge densities (θ) were obtained using a membrane potential method, and these θ valuse increased with M/G ratio, and dissociation of the carboxylic groups of uronates was found to be suppressed significantly in the network. The permeability coefficients (P) of sodium benzoate through the membranes decreased with increasing M/G ratio. The P values are discussed in terms of electrostatic interaction, structure of the gel network, and bound and restricted water.
公益社団法人日本薬学会の論文
1999-08-15