Supercritical Fluid Extraction and Liquid Chromatography-Electrospray Mass Analysis of Vinblastine from Catharanthus roseus
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概要
- 論文の詳細を見る
Supercritical fluid extraction using carbon dioxide modified with methanol, methanol-diethylamine, or methanol-triethylamine was used to extract vinblastine from the aerial portions of Catharanthus roseus. An HPLC-electrospray ionization (ESI)/MS analysis method was also developed to quantify the alkaloids in these extracts. Of the supercritical solvents evaluated, carbon dioxide-methanol-triethylamine (80:18:2) at 80℃ and 34.0 MPa greatly improved the supercritical fluid extraction (SFE) yield of vinblastine by as much as 76.4% over methanol extraction, while the other solvent conditions extracted the compound at yields less than 25% that of a methanol extraction. These results were confirmed by the robust HPLC-ESI/MS analytical method developed in this study.
- 公益社団法人日本薬学会の論文
- 2002-09-01
著者
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YOO Ki-Pung
Department of Chemical Engineering, Sogang University
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Kim Jinwoong
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Choi Young
Greentek21 Co. Ltd.:college Of Pharmacy And Research Institute Of Pharmaceutical Sciences Seoul Nati
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Yoo Ki-pung
Department Of Chemical Engineering Sogang University
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