5-Demethoxyfumagillol, a Potent Angiogenesis Inhibitor Isolated from Aspergillus fumigatus
スポンサーリンク
概要
- 論文の詳細を見る
A novel angiogenesis inhibitor, 5-demethoxyfumagillol (1), was obtained by isolation, purification and saponification of cultured broth of Aspergillus fumigatus. The structure was assigned as (3R, 4R, 6R) -4- [(2R, 3R) -2-methyl-3- (3-methyl-but-2-enyl) -oxiranyl] -1-oxa-spiro [2, 5] octan-6-ol (1) by spectroscopic analysis and confirmed by independent synthesis from fumagillol (3). In addition, 6-O-(chloroacetylcarbamoyl) -5-demethoxyfumagillol (7) showed a potential anti-angiogenic activity in CAPE cells in vitro.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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Ahn Soon
New Drug Research Laboratories Chong Kun Dang Research Institute
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Ahn Soon
New Drue Research Laboratories Chong Kun Dang Research Institute
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Choi Nam
New Drue Research Laboratories Chong Kun Dang Research Institute
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LEE Hong
New Drug Research Laboratories, Chong Kun Dang Research Institute
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Moon Seung
New Drue Research Laboratories Chong Kun Dang Research Institute
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Kim Deukjoon
Research Institute Of Pharmaceutical Sciences College Of Pharmacy Seoul National University
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Lee H
New Drue Research Laboratories Chong Kun Dang Research Institute
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Lee Hong
New Drug Research Laboratories Chong Kun Dang Research Institute
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MIN Jaeki
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University
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Min Jaeki
Research Institute Of Pharmaceutical Sciences College Of Pharmacy Seoul National University
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LEE Hong
New Drue Research Laboratories, Chong Kun Dang Research Institute
関連論文
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- 5-Demethoxyfumagillol, a Potent Angiogenesis Inhibitor Isolated from Aspergillus fumigatus
- Efficient Synthesis of Dichlorodenafil, an Unapproved Sildenafil Analogue Appearing in Non-prescription Supplements