Efficient Synthesis of Dichlorodenafil, an Unapproved Sildenafil Analogue Appearing in Non-prescription Supplements

スポンサーリンク

概要

• 論文の詳細を見る

• We have developed an efficient synthesis of dichlorodenafil (4), an unapproved sildenafil analogue isolated from dietary supplements. Our sequence employs POCl3-mediated chlorination of readily available chloroacetyl compound 7 followed by selective hydrolysis of the chloro-heterocycle function. Our synthesis confirms the structure of the illegal additive, and will provide regulatory agencies with ready access to authentic standard samples of dichlorodenafil (4) to aid in their mission to protect the public from unapproved and potentially harmful erectile dysfunction (ED) drug analogues that are added to herbal and dietary supplements without providing users with appropriate toxicological or pharmacological information.

著者

• Kim Jong

  Research Center For Dielectric And Advanced Matter Physics Pusan National University

• Kim Deukjoon

  Research Institute Of Pharmaceutical Sciences College Of Pharmacy Seoul National University

• Kwon Sung

  Research Institute Of Pharmaceutical Sciences And College Of Pharmacy Seoul National University

• Oh Jae

  Korea Food and Drug Administration

• Hwang In

  Korea Food and Drug Administration

• Kang Il

  Korea Food and Drug Administration

関連論文

• Crystallization and Conduction Mechanisms on Amorphous PbTiO_3
• Ferroelectric Properties of Tungsten-Substituted Bi_4Ti_3O_ Thin Film Prepared by Sol-Gel Method
• 5-Demethoxyfumagillol, a Potent Angiogenesis Inhibitor Isolated from Aspergillus fumigatus
• Determination of proteins in infant formula by high-performance liquid chromatography-electrospray tandem mass spectrometry
• Determination of volatile biomarkers for apoptosis and necrosis by solid-phase microextraction-gas chromatography/mass spectrometry : A pharmacometabolomic approach to cisplatin's cytotoxicity to human lung cancer cell lines
• ヒラメに対する Edwardsiella tarda-Streptococcus iniae-Streptococcus parauberis 3 種混合ワクチンの有効性
• Efficient Synthesis of Dichlorodenafil, an Unapproved Sildenafil Analogue Appearing in Non-prescription Supplements

スポンサーリンク