Design, Synthesis, and Antiangiogenic Effects of a Series of Potent Novel Fumagillin Analogues
スポンサーリンク
概要
- 論文の詳細を見る
A series of fumagillin analogues containing the C6-substituted cinnamoyl moiety were designed, synthesized, and evaluated for antiangiogenic activity. Among them, 4-hydroxyethoxy-cinnamoyl fumagillol (4a) and 4-hydroxyethoxy-3,5-dimethoxycinnamoyl fumagillol (4d) exhibited more potent anti-proliferation activity in CPAE and HUVEC cells with low cytotoxicity in vitro. These compounds are presently under further pharmacological evaluation studies.
- 公益社団法人日本薬学会の論文
- 2007-07-01
著者
-
Cho Chin
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Ahn Soon
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Ahn Soon
New Drue Research Laboratories Chong Kun Dang Research Institute
-
Kang Sung
Chong Kun Dang Res. Inst. Chonan Kor
-
LEE Hong
New Drug Research Laboratories, Chong Kun Dang Research Institute
-
KANG Sung
New Drug Research Laboratories, Chong Kun Dang Research Institute
-
YOO Yong
New Drug Research Laboratories, Chong Kun Dang Research Institute
-
SHIN Jae
New Drug Research Laboratories, Chong Kun Dang Research Institute
-
Yoo Yong
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Lee Hong
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Kang Sung
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Shin Jae
New Drug Research Laboratories Chong Kun Dang Research Institute
-
LEE Hong
New Drue Research Laboratories, Chong Kun Dang Research Institute
関連論文
- Design, Synthesis, and Antiangiogenic Effects of a Series of Potent Novel Fumagillin Analogues
- Formation of Bi2212 Phase via Bi2201 Phase in Liquid-Phase Epitaxial Growth
- Effect of Y Substitution for Ca in Bi_2Sr_2CaCu_2O_ Superconducting Films Prepared by Liquid Phase Epitaxial Method
- X-ray Photoelectron Spectroscopy Study in Bi_2Sr_2Ca_Nd_xCu_2O_
- Effect of Ni Substitution for Cu in 110 K Phase of (Bi, Pb)-Sr-Ca-Cu-O Superconductors
- Effect of Y Substitution for the Ca Site in the 110 K Phase of (Bi, Pb)-Sr-Ca-Cu-O Superconductors
- XPS Study on the Formation Process of the High-T_c Phase in the Bi-Pb-Sr-Ca-Cu-O System
- Synthesis and Antihyperglycemic Activity of Erythrose, Ribose and Substituted Pyrrolidine Containing Thiazolidinedione Derivatives
- 5-Demethoxyfumagillol, a Potent Angiogenesis Inhibitor Isolated from Aspergillus fumigatus