Synthesis and Antihyperglycemic Activity of Erythrose, Ribose and Substituted Pyrrolidine Containing Thiazolidinedione Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A series of erythrose, ribose, and substituted pyrrolidine containing 2, 4-thiazolidinediones were synthesized. Among them, thirteen unsaturated thialolidinediones, six saturated thiazolidinediones and two unsaturated malonates were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. On the basis of the in vitro activity, 5-{4-[2-(1-benzyl-3, 4-bis-benzyloxypyrrolidin-2-yl)ethoxy]benzylidene}thiazolidine-2, 4-dione 24b was selected as the candidate for further pharmacological studies.
- 公益社団法人日本薬学会の論文
- 2003-03-01
著者
-
CHANG Hung-Bae
CKD Research Institute
-
AHN Soon
CKD Research Institute
-
Ahn S
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Ahn S
Ckd Res. Inst. Chonan Kor
-
Hong Chung
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Moon K
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Ahn Soon
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Ahn Soon
New Drue Research Laboratories Chong Kun Dang Research Institute
-
Shin J
Department Of Physics Taejon University
-
Moon Kyoung
New Drug Research Laboratories Chong Kun Dang Research Institute
-
SHIN Jae
New Drug Research Laboratories, Chong Kun Dang Research Institute
-
KIM Bok
New Drug Research Laboratories, Chong Kun Dang Research Institute
-
AHN Joong
New Drug Research Laboratories, Chong Kun Dang Research Institute
-
KEE Hong
New Drug Research Laboratories, Chong Kun Dang Research Institute
-
SIM Tae
New Drug Research Laboratories, Chong Kun Dang Research Institute
-
Sim Tae
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Kee Hong
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Ahn J
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Lee Hong
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Shin J
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Kim B
New Drug Research Laboratories Chong Kun Dang Research Institute
-
Shin Jae
New Drug Research Laboratories Chong Kun Dang Research Institute
-
LEE Hong
New Drue Research Laboratories, Chong Kun Dang Research Institute
関連論文
- Novel α-Glucosidase Inhibitors, CKD-711 and CKD-711a Produced by Streptomyces sp. CK-4416 III. Physico-chemical Properties and Structure Elucidation
- Novel α-Glucosidase Inhibitors, CKD-711 and CKD-711a Produced by Streptomyces sp. CK-4416 II. Biological Properties
- Design, Synthesis, and Antiangiogenic Effects of a Series of Potent Novel Fumagillin Analogues
- Formation of Bi2212 Phase via Bi2201 Phase in Liquid-Phase Epitaxial Growth
- Effect of Y Substitution for Ca in Bi_2Sr_2CaCu_2O_ Superconducting Films Prepared by Liquid Phase Epitaxial Method
- X-ray Photoelectron Spectroscopy Study in Bi_2Sr_2Ca_Nd_xCu_2O_
- Effect of Ni Substitution for Cu in 110 K Phase of (Bi, Pb)-Sr-Ca-Cu-O Superconductors
- Effect of Y Substitution for the Ca Site in the 110 K Phase of (Bi, Pb)-Sr-Ca-Cu-O Superconductors
- XPS Study on the Formation Process of the High-T_c Phase in the Bi-Pb-Sr-Ca-Cu-O System
- Novel α-Glucosidase Inhibitors, CKD-711 and CKD-711a Produced by Streptomyces sp. CK-4416
- Synthesis and Antihyperglycemic Activity of Erythrose, Ribose and Substituted Pyrrolidine Containing Thiazolidinedione Derivatives
- 5-Demethoxyfumagillol, a Potent Angiogenesis Inhibitor Isolated from Aspergillus fumigatus