Preparation of Deuterated Methyl and Dimethyl Substituted Nicotinoylating Agents for Derivatization of the N-Terminal of Protein
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概要
- 論文の詳細を見る
Methyl groups of 6-methylnicotinic acid and 2,6-dimethylnicotinic acid were deuterated by an H-D exchange reaction under conditions of 1% NaOD/D_2O on heating. With a condensation reaction between the D-labeled nicotinic acid derivative and N-hydroxysuccinimide with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, the nicotinoylating agents, 1-(6-methyl[D_3]nicotinoyloxy)succinimide (2c) and 1-(2,6-dimethyl-[D_6]nicotinoyloxy)succinimide (2f) were prepared. Both D-labeled nicotinoylating agents and their unlabeled counterparts quantitatively modified the N-terminal of protein.
- 公益社団法人日本薬学会の論文
- 2003-12-01
著者
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MIYATA Naoki
Graduate School of Pharmaceutical Sciences, Nagoya City University
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Taguchi R
Nagoya City Univ. Nagoya Jpn
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Taguchi Ryo
Univ. Tokyo Tokyo
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Taguchi Ryo
Graduate School Of Medicine The University Of Tokyo
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TSUMOTO Hiroki
Graduate School of Pharmaceutical Sciences, Nagoya City University
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MURATA Chie
Graduate School of Pharmaceutical Sciences, Nagoya City University
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KOHDA Kohfuku
Graduate School of Pharmaceutical Sciences, Nagoya City University
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Miyata Naoki
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Murata Chie
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Kohda Kohfuku
Graduate School Of Pharmaceutical Sciences Nagoya City University
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