The Antiproliferative Activity of Saponin-Enriched Fraction from Bupleurum Kaoi Is through Fas-Dependent Apoptotic Pathway in Human Non-small Cell Lung Cancer A549 Cells(Miscellaneous)
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概要
- 論文の詳細を見る
Bupleuri Radix (Chai-hu in Chinese and Saiko in Japanese) is one of the most important traditional Chinese crude drugs for treating hepatitis malaria and intermittent fever. B. kaoi is one of the Bupleurum spp. families locally found in Taiwan. The effects of saponin-enriched fraction (SEF) from Bupleurum Kaoi in human non-small cell lung cancer A549 cells were investigated in this study. An enhancement in Fas and its two forms of ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), was responsible for the apoptotic effect induced by SEF. Taken together, our study suggests that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of SEF in A549 cells.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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Chiang Lien-chai
Faculty Of Pharmacy College Of Pharmacy Kaohsiung Medical University
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LIN Chun-Ching
Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University
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Yen Ming-hong
Faculty Of Pharmacy College Of Pharmacy Kaohsiung Medical University
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KUO Po-Lin
Department of Biotechnology, Chia-Nan University of Pharmacy and Science
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HSU Ya-Ling
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University
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KUO Po-Lin
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University
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WENG Ting-Chun
Department of Pharmacy, Chia-Nan University of Pharmacy and Science
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YEN Ming-Hong
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University
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CHIANG Lien-Chai
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University
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Hsu Ya-ling
Department Of Pharmacy Chia-nan University Of Pharmacy And Science
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Weng Ting-chun
Graduate Institute Of Natural Products College Of Pharmacy Kaohsiung Medical University
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Lin Chun
Graduate Institute Of Natural Products Kaohsiung Medical University
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Kuo Po-lin
Dep. Of Biotechnology Chia-nan Univ. Of Pharmacy And Sci.
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Lin Chun-ching
中華人民共和国
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Lin Chun-ching
Graduate Institute Of Pharmaceutical Science College Of Pharmacy Kaohsiung Medical University
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Lin Chun-Ching
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University
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