The Hepatoprotective Effect of Bupleurum kaoi, an Endemic Plant to Taiwan, against Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats(Pharmacology)

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概要

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• In the present study, three materials extracted or isolated from the roots of B. kaoi, an endemic plant to Taiwan, were used to be examined the hepatoprotective effect against dimethylnitrosamine (DMN)-induced hepatic fibrosis in rats, they were water extract (BKW), polysaccharide-enriched fractions (BKP) and saponin-enriched fractions (BKS). After treated with DMN for 4 weeks, the levels of aminotrasferases (GOT, GPT) were significantly elevated in serum, and the levels of total protein (TP) and albumin were significantly decreased in serum and liver homogenates. Furthermore, the collagen contents were significantly elevated in liver homogenates and corresponded to the hepatofibrotic pathological examination. As the results showed, treated with groups of BKW, BKP, BKS markedly reduced GOT, GPT levels in rats serum. In addition, treated with groups of BKW, BKP, BKS markedly raised TP levels in rats serum and liver homogenates. Furthermore, treated with groups of BKW, BKP markedly raised albumin levels in rats serum and liver homogenates. Treated with groups of BKW, BKP, BKS markedly raised interferon-γ (IFN-γ) levels in rats serum, where only BKS and silymarin markedly raised interkeukin-10 (IL-10) levels in rats serum compared to that of DMN treated rats. None of test materials of B. kaoi except silymarin reduced the malondialdehyde (MDA) levels, but BKW, BKP markedly raised hepatic glutathione (GSH) levels to reveal the activity of anti-lipid peroxidation. Otherwise, treated with groups of BKW, BKP, BKS significantly reduced collagen contents in rats liver homogenates. In conclusion, B. kaoi demonstrated the anti-inflammatory and anti-fibrotic activities followed by anti-oxidant activity of enhanced GSH production, enhanced the liver cell regeneration and concerned with regulations of INF-γ and IL-10. The ability of hepato-protective and anti-fibrotic activities of B. kaoi are higher than B. chinense, a Bupleuri Radix imported from China to Taiwan.

• 公益社団法人日本薬学会の論文
• 2005-03-01

著者

• Chiang Lien-chai

  Faculty Of Pharmacy College Of Pharmacy Kaohsiung Medical University

• Yen Ming-hong

  Faculty Of Pharmacy College Of Pharmacy Kaohsiung Medical University

• YEN Ming

  Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University

• WENG Ting

  Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University

• LIU Sin

  Senior Agronomist, Agronomy Division, Agricultural Research Institute, Council of Agriculture

• CHAI Chee

  Department of Pathology, College of Medicine, Kaohsiung Medical University

• LIN Chun

  Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University

• YEN Ming-Hong

  Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University

• Weng Ting-chun

  Graduate Institute Of Natural Products College Of Pharmacy Kaohsiung Medical University

• Chai Chee

  Department Of Pathology College Of Medicine Kaohsiung Medical University

• Lin Chun

  Graduate Institute Of Natural Products Kaohsiung Medical University

• Liu Sin

  Senior Agronomist Agronomy Division Agricultural Research Institute Council Of Agriculture

• Lin Chun-ching

  中華人民共和国

• Liu Sin-Yie

  Senior Agronomist, Agronomy Division, Agricultural Research Institute, Council of Agriculture, Taiwan

• LIN Chun

  Graduate Institute of Clinical Dentistry, College of Medicine, National Taiwan University and National Taiwan University Hospital

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