Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of some Novel 2-Methylthio-3-Substituted Quinazolin-4-(3H)-ones (Medicinal Chemistry)

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概要

• 論文の詳細を見る

• A variety of novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones have been synthesized by reacting (2-methylthio-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with a variety of amines, the starting material dithiocarbamate was synthesized from methylanthranilate. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. While the test compounds exhibited significant activity, the compounds A1, A2, A3 and A4 shown more potent analgesic activity, and the compound A4 shown more potent anti-inflammatory activity than the reference diclofenac sodium.

• 公益社団法人日本薬学会の論文
• 2004-05-01

著者

• Alagarsamy Veerachamy

  Medicinal Chemistry Laboratory J.s.s. College Of Pharmacy

• Ramaseshu Meena

  Department Of Pharmaceutical Chemistry K.m. College Of Pharmacy

• RAJESH Ramadoss

  Medicinal Chemistry Laboratory, J.S.S. College of Pharmacy

• VIJAYKUMAR Sukumaran

  Department of Pharmaceutical Chemistry, K.M. College of Pharmacy

• RAMSESH Kona

  Department of Pharmaceutical Chemistry, K.M. College of Pharmacy

• DURAIANANDAKUMAR Thirumoorthy

  Department of Pharmaceutical Chemistry, K.M. College of Pharmacy

• Rajesh Ramadoss

  Medicinal Chemistry Laboratory J.s.s. College Of Pharmacy

• Ramsesh Kona

  Department Of Pharmaceutical Chemistry K.m. College Of Pharmacy

• Duraianandakumar Thirumoorthy

  Department Of Pharmaceutical Chemistry K.m. College Of Pharmacy

• Vijaykumar Sukumaran

  Department Of Pharmaceutical Chemistry K.m. College Of Pharmacy

関連論文

• Synthesis and H_1-Antihistaminic Activity of Some Novel 1-Substituted-4-(3-methylphenyl)-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones(Medicinal Chemistry)
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Phenyl-3-substituted Quinazolin-4(3H) Ones
• Synthesis, Analgesic and Anti-inflammatory Activities of Some Novel 2,3-Disubstituted Quinazolin-4(3H)-ones
• Synthesis and Pharmacological Evaluation of Some 3-(4-Methoxyphenyl)-2-substitutedamino-quinazolin-4(3H)-ones as Analgesic and Anti-inflammatory Agents
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Butyl-3-substituted Quinazolin-4-(3H)-ones(Medicinal Chemistry)
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of some Novel 2-Methylthio-3-Substituted Quinazolin-4-(3H)-ones (Medicinal Chemistry)
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Methyl-3-substituted Quinazolin-4-(3H)-ones (Medicinal Chemistry)

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