Synthesis, Analgesic and Anti-inflammatory Activities of Some Novel 2,3-Disubstituted Quinazolin-4(3H)-ones

スポンサーリンク

概要

• 論文の詳細を見る

• A series of novel 2-benzylamino-3-substituted quinazolin-4(3H)-ones have been synthesized by treating 3-amino-2-benzylamino quinazolin-4(3H)-one, with different aldehydes and ketones. The starting material 3-amino-2-ben/yIamino quinazolin-4(3H)-one was synthesized by nucleophilic substitution of thiontethyl group of 3-amino-2-methylthio quinazolin-4(3H)-one by benzylamine. The title compounds were investigated for analgesic and anti-inflammatory activities. All the test compounds exhibited significant analgesic activity, whereas the compound III is equipotent with diclofenac sodium. The compounds I, II and III showed more potent anti-inflammatory activity than diclofenac sodium.

• 公益社団法人日本薬学会の論文
• 2003-04-01

著者

• ALAGARSAMY Veerachamy

  Medicinal Chemistry Laboratory, Periyar College of Pharmaceutical Sciences for Girls

• Revathi Rajappan

  Medicinal Chemistry Laboratory S.b.college Of Pharmacy

• MUTHUKUMAR Veluchamy

  Medicinal Chemistry Laboratory, S.B.College of Pharmacy

• PAVALARANI Nagendran

  Medicinal Chemistry Laboratory, S.B.College of Pharmacy

• VASANTHANATHAN Poongavanam

  Medicinal Chemistry Laboratory, S.B.College of Pharmacy

• Vasanthanathan Poongavanam

  Medicinal Chemistry Laboratory S.b.college Of Pharmacy

• Alagarsamy Veerachamy

  Medicinal Chemistry Laboratory J.s.s. College Of Pharmacy

• Alagarsamy Veerachamy

  Medicinal Chemistry Laboratory S.b.college Of Pharmacy

• Pavalarani Nagendran

  Medicinal Chemistry Laboratory S.b.college Of Pharmacy

• Muthukumar Veluchamy

  Medicinal Chemistry Laboratory S.b.college Of Pharmacy

関連論文

• Synthesis and H_1-Antihistaminic Activity of Some Novel 1-Substituted-4-(3-methylphenyl)-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones(Medicinal Chemistry)
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Phenyl-3-substituted Quinazolin-4(3H) Ones
• Synthesis, Analgesic and Anti-inflammatory Activities of Some Novel 2,3-Disubstituted Quinazolin-4(3H)-ones
• Synthesis and Pharmacological Evaluation of Some 3-(4-Methoxyphenyl)-2-substitutedamino-quinazolin-4(3H)-ones as Analgesic and Anti-inflammatory Agents
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Butyl-3-substituted Quinazolin-4-(3H)-ones(Medicinal Chemistry)
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of some Novel 2-Methylthio-3-Substituted Quinazolin-4-(3H)-ones (Medicinal Chemistry)
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Methyl-3-substituted Quinazolin-4-(3H)-ones (Medicinal Chemistry)

スポンサーリンク