Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Butyl-3-substituted Quinazolin-4-(3H)-ones(Medicinal Chemistry)

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概要

• 論文の詳細を見る

• A variety of novel 2-butyl-3-substituted quinazolin-4-(3H)-ones have been synthesized by reacting (2-butyl-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with a variety of amines; the starting material dithiocarbamate was synthesized from anthranilic acid. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. While the test compounds exhibited significant activity, compounds A1, A2, A3 and A4 showed more potent analgesic activity and compound A4 showed more potent anti-inflammatory activity than the reference diclofenac sodium.

• 公益社団法人日本薬学会の論文
• 2005-06-01

著者

• Alagarsamy Veerachamy

  Medicinal Chemistry Res. Lab. Arulmigu Kalasalingam Coll. Of Pharmacy

• Alagarsamy Veerachamy

  Medicinal Chemistry Laboratory J.s.s. College Of Pharmacy

• Meena Ramseshu

  Department Of Pharmaceutical Chemistry K.m. College Of Pharmacy

• RAJASOLOMON Viswas

  Medicinal Chemistry Laboratory, Central Drug Research Institute

• RAMSESHU Kona

  Department of Pharmaceutical Chemistry, K.M. College of Pharmacy

• Rajasolomon Viswas

  Medicinal Chemistry Laboratory Central Drug Research Institute

• RAMSESHU Kona

  Department of Pharmaceutical Chemistry, K. M. College of Pharmacy

関連論文

• Synthesis and H_1-Antihistaminic Activity of Some Novel 1-Substituted-4-(3-methylphenyl)-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones(Medicinal Chemistry)
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Phenyl-3-substituted Quinazolin-4(3H) Ones
• Synthesis, Analgesic and Anti-inflammatory Activities of Some Novel 2,3-Disubstituted Quinazolin-4(3H)-ones
• Synthesis and Pharmacological Evaluation of Some 3-(4-Methoxyphenyl)-2-substitutedamino-quinazolin-4(3H)-ones as Analgesic and Anti-inflammatory Agents
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Butyl-3-substituted Quinazolin-4-(3H)-ones(Medicinal Chemistry)
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of some Novel 2-Methylthio-3-Substituted Quinazolin-4-(3H)-ones (Medicinal Chemistry)
• Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Methyl-3-substituted Quinazolin-4-(3H)-ones (Medicinal Chemistry)

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