Identification of Selenoprotein P Fragments as a Cell-Death Inhibitory Factor
スポンサーリンク
概要
- 論文の詳細を見る
Megakaryoblastoma (Dami cells) cultured in a serum-free medium containing albumin, proliferated for three days but died on the fourth day. This cell death was not observed when human plasma was added, suggesting that human plasma contains a cell-death inhibitory factor. In order to identify this factor, we purified it from human plasma. N-terminal amino acid sequence analysis revealed that this factor is a mixture of C-terminal fragments of seienoprotein P, a major selenocysteine-containing protein in plasma. The specific activity (unit per pmol of selenium) of seienoprotein P fragments protein was 15-fold and 1900-fold higher than that of the full-length SeP and sodium selenite, respectively.
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
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Saito Yoshiro
化学及血清療法研究所
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Saito Y
Department Of Hygienic Chemistry Graduate School Of Pharmaceutical Sciences Hokkaido University:huma
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HIRASHIMA Masaki
Research Department 1, The Chemo-Sero-Therapeutic Research Institute
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NOZAKI Chikateru
Research Department 1, The Chemo-Sero-Therapeutic Research Institute
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Takahashi K
Center For Food Quality Labeling And Consumer Services:national Food Research Institute
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Takahashi Kazuhiko
Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya Ci
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Saito Yoshiro
Department Of Hygienic Chemistry Graduate School Of Pharmaceutical Sciences Hokkaido University
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NOZAKI CHIKATERU
The Chemo-Sero-Therapeutic Research Institute
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HIRASHIMA Masaki
The Chemo-Sero-Therapeutic Research Institute
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NARUSE Takeshi
The Chemo-Sero-Therapeutic Research Institute
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MAEDA Hiroaki
The Chemo-Sero-Therapeutic Research Institute
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Takahashi Kazuhiko
Center For Food Quality Labeling And Consumer Services:national Food Research Institute
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Nozaki Chikateru
Research Department 1 The Chemo-sero-therapeutic Research Institute
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Hirashima Masaki
Research Department 1 The Chemo-sero-therapeutic Research Institute
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Takahashi Kazuhiko
Department Of Cardiovascular Diseases Miyagi Prefectural Semine Hospital
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Takahashi Kazuhiko
Department Of Applied Chemistry Tokyo Institute Of Technology
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