超常磁性酸化鉄粒子の肝臓用造影剤としての基礎実験

概要

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An superparamagnetic iron oxide particle preparation was evaluated as a potential contrast medium for liver MRI. This contrast medium, administered intravenously, is expected to provide a negative contrasting effect by reducing the signal intensity in the normal portions of the liver and to enhance the MR image of the tumor. After administration of this preparation, T1 and T2 values were shortened. The signal intensity decreased more linearly in the T2-weighted than T1-weighted image. In clinical studies, the degree of the decrease in the signal intensity in the normal portions of the liver was greater with the dose, in the T2-weighted than T1-weighted image, and in the spin-echo than field-echo mode. CNR was increased after as compared with before administration in both the normal and tumoral portions of the liver. From these findings, this contrast medium is considered to markedly enhance the contrast between the normal and tumoral tissues of the liver especially in T2-weighted images of MRI and to be useful for MRI studies of liver tumor.
公益社団法人日本放射線技術学会の論文
1992-05-01