可変Flip Angle SPGRによる造影ダイナミックT_1値計測MRI

概要

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We modified the multi-phase spoiled gradient recalled echo (SPGR.) pulse sequence using the double-echo MR technique for estimation of T_1 during the first pass of contrast agent, and examined its precision. In the first half of the pulse sequence, the flip angle was varied systematically to calculate static T_1 values. It was necessary to choose optimal flip angles to minimize the calculation error of static T_1 values. In the latter half of this sequence, changes in absolute T_1 were calculated using differences in signal intensities before and after the injection of contrast agent. The optimal flip angle was 20 degrees for precise conversion to T_1 values under the short TR(33.3 ms)condition. Double echo MR data were used to minimize the T_2 effect. The present method appears to be useful for quantitative estimation of dynamic contrast-enhanced MRI.
社団法人日本放射線技術学会の論文
2003-12-20