Presence and Phylogenetic Relationships of a Hominoid-Specific Retroposon Family on the Human Y Chromosome(Phylogeny)

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概要

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• The retroposon SINE-R. C2 was first identified as a human-specific insertion in the complement C2 gene and the insertion of a closely related element has been implicated as a cause of Fukuyama type muscular dystrophy. In a previous study, we found SINE-R-type retroposons, derived from the endogenous retrovirus HERV-K family, have been found to be hominoid specific. In this report, we identified twelve SINE-R-type retroposons from the human Y chromosome by a PCR approach. Compared with other human retroposons (SINE-R. C2, 11, 14, 19, and HS307/HS408), the Y-chromosomal retroposon showed a high degree of sequence homology (86-96%). Phylogenetic analysis using the neighbor-joining method revealed that SINE-R-type retroposons on the Y chromosome were inter-related with hominoid primates, suggesting that SINE-R elements on the Y chromosome have evolved progressively in the hominoid radiation. Two elements SINE-R.Y-2 and Y-7 are more closely related to the human-specific retroposon SINE-R.C2 than other Y-chromosomal retroposons. Such elements thus are likely to be of great potential relevance to recent events in hominoid evolution and to structural change or genetic variation connected to various disease.

• 社団法人日本動物学会の論文
• 1999-12-15

著者

• Kim Heui-soo

  Powic Department Of Psychiatry Warneford Hospital University Of Oxford

• CROW Timothy

  POWIC, Department of Psychiatry, Warneford Hospital, University of Oxford

• Crow Timothy

  Powic Department Of Psychiatry Warneford Hospital University Of Oxford

• Crow T

  Univ. Oxford Oxford Gbr

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• Presence and Phylogenetic Relationships of a Hominoid-Specific Retroposon Family on the Human Y Chromosome(Phylogeny)
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