Presence and phylogenetic analysis of HERV-K LTR on human X and Y chromosomes : Evidence for recent proliferation

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概要

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• The K group of human endogenous retroviruses (HERV-K) has been suggested to have a role in disease and has recently been shown to include long terminal repeat (LTR) elements that are human specific. Here we investigated the presence of HERV-K LTRs on the human X and Y chromosomes with the use of PCR on a monochromosomal somatic cell hybrid DNA panel. We report twelve such sequences on the X chromosome and ten sequences on the Y chromosome. Phylogenetic analysis reveals that clones X2, 4, 5, 6, 7, 11, 15 from the X chromosome and clones Y4, 5, 7, 10 from the Y chromosome are closely related to the human-specific members of Medstrand and Magers cluster 9. The sequence of clone Y7 from the Y chromosome is identical with human-specific HERV-K LTR element (AC002350) from chromosome 12q24. The findings suggest recent proliferation and transposition of HERV-K LTR elements on these chromosomes. Such events may have contributed to structural change and genetic variation in the human genome. We draw attention to evolutionarily recent changes in homologies between X and Y chromosomes as a method of further investigating such transpositions.

• 日本遺伝学会の論文

著者

• Kim Heui-soo

  Powic Department Of Psychiatry Warneford Hospital University Of Oxford

• Kim Heui-soo

  Powic Department Of Psychiatry Warneford Hospital University Of Oxfprd

• CROW Timothy

  POWIC, Department of Psychiatry, Warneford Hospital, University of Oxford

• Crow Timothy

  Powic Department Of Psychiatry Warneford Hospital University Of Oxford

• Crow Timothy

  Powic Department Of Psychiatry Warneford Hospital University Of Oxfprd

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• Presence and phylogenetic analysis of HERV-K LTR on human X and Y chromosomes : Evidence for recent proliferation
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