Transposable elements in human cancers by genome-wide EST alignment

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概要

• 論文の詳細を見る

• Transposable elements may affect coding sequences, splicing patterns, and transcriptional regulation of human genes. Particles of the transposable elements have been detected in several tissues and tumors. Here, we report genome-wide analysis of gene expression regulated by transposable elements in human cancers. We adopted an analysis pipeline for screening methods to detect cancer-specific expression from expressed human sequences. We developed a database (TECESdb) for understanding the mechanism of cancer development in relation to transposable elements. A total of 999 genes fused with transposable elements were found to be cancer-related in our analysis of the EST database. According to GO (Gene Ontology) analysis, the majority of the 999 cancer-specific genes have functional association with gene receptor, DNA binding, and kinase activity. Our data could contribute greatly to our understanding of human cancers in relation to transposable elements.

• 日本遺伝学会の論文
• 2007-04-25

著者

• Huh Jae-Won

  National Primate Research Center (NPRC), KRIBB

• Kim Dae-soo

  National Primate Res. Center (nprc) Kribb

• Kim Heui-soo

  Div. Of Biological Sciences Coll. Of Natural Sciences Pusan National Univ.

• Kim Heui-soo

  Powic Department Of Psychiatry Warneford Hospital University Of Oxford

• KIM Dae-Soo

  PBBRC, Interdisciplinary Research Program of Bioinformatics, Pusan National University

• HUH Jae-Won

  Division of Biological Sciences, College of Natural Sciences, Pusan National University

• KIM Heui-Soo

  PBBRC, Interdisciplinary Research Program of Bioinformatics, Pusan National University

• Kim H‐s

  Powic Department Of Psychiatry Warneford Hospital University Of Oxford

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