Endogenous retrovirus-related sequences provide an alternative transcript of MCJ genes in human tissues and cancer cells

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概要

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• The MCJ gene is a member of the DNAJ family, and its transcriptional event is controlled by methylation of the CpG island. In our study, we found LTR33 and LTR7 elements provided an alternative transcript within the MCJ gene. To detect different expression patterns between the originally reported MCJ transcript and the LTR-related transcript, we performed a RT-PCR approach using various human tissues and cancer cells. The original MCJ transcript was detected in human tissues and cancer cells, whereas the LTR-related transcript was only revealed in some cancer cells (HCT106, MCF-3, TE-1, Hela, and CCHM). We also performed a PCR analysis to compare the insertion lineage of the LTR elements with the genomic DNAs of primates, indicating that those LTR33 and LTR7 elements of HERV-H have been integrated into the primate genome at different times. Taken together, we suggest that HERV-related elements trigger transcriptome diversification during primate evolution.

• 日本遺伝学会の論文
• 2006-10-25

著者

• Huh Jae-Won

  National Primate Research Center (NPRC), KRIBB

• Kim Heui-Soo

  Division of Biological Sciences, College of Natural Sciences, Pusan National University

• Sin Ho-su

  韓国

• Sin Ho-su

  Division Of Biological Sciences College Of Natural Sciences Pusan National University

• Kim Dae-soo

  National Primate Res. Center (nprc) Kribb

• Kim Heui-soo

  Div. Of Biological Sciences Coll. Of Natural Sciences Pusan National Univ.

• Kim Heui-soo

  Division Of Biological Sciences College Of Natural Sciences Pusan National University

• Kim Heui-soo

  Powic Department Of Psychiatry Warneford Hospital University Of Oxford

• KIM Dae-Soo

  PBBRC, Interdisciplinary Research Program of Bioinformatics, Pusan National University

• HUH Jae-Won

  Division of Biological Sciences, College of Natural Sciences, Pusan National University

• KIM Tae-Hong

  Division of Biological Sciences, College of Natural Sciences, Pusan National University

• HA Hong-Seok

  Division of Biological Sciences, College of Natural Sciences, Pusan National University

• KIM Woo-Yeon

  PBBRC, Interdisciplinary Research Program of Bioinformatics, Pusan National University

• PARK Hee-Kyung

  Institute for Genomic Medicine, GENEIN Co.

• KIM Cheol-Min

  Department of Biochemistry, College of Medicine, Pusan National University

• Park Hee-kyung

  Institute For Genomic Medicine Genein Co.

• Kim Tae-hong

  Division Of Biological Sciences College Of Natural Sciences Pusan National University

• Kim H‐s

  Powic Department Of Psychiatry Warneford Hospital University Of Oxford

• Ha Hong-seok

  Division Of Biological Sciences College Of Natural Sciences Pusan National University

• Kim Woo-yeon

  Pbbrc Interdisciplinary Research Program Of Bioinformatics Pusan National University

• Kim Cheol-min

  Department Of Biochemistry College Of Medicine Pusan National University

関連論文

• Four different ways of alternative transcripts generation mechanism in ADRA1A gene
• Transposable elements in human cancers by genome-wide EST alignment
• Endogenous retrovirus-related sequences provide an alternative transcript of MCJ genes in human tissues and cancer cells
• Identification and phylogenetic analysis of novel human endogenous retroviral sequences belonging to the HERV-H family on human X and Y chromosomes
• Evolutionary implication of human endogenous retrovirus HERV-H family
• Phylogenetic analysis of a retroposon family as represented on the human X chromosome
• Presence and phylogenetic analysis of HERV-K LTR on human X and Y chromosomes : Evidence for recent proliferation
• Analysis of newly identified low copy AluYj subfamily
• Presence and Phylogenetic Relationships of a Hominoid-Specific Retroposon Family on the Human Y Chromosome(Phylogeny)
• Molecular Phylogenetic Analysis of the Human Endogenous Retrovirus E (HERV-E) Family in Human Tissues and Human Cancers
• Expression and Identification of HERV-W Family in Japanese Monkeys (Macaca fuscata)
• Four different ways of alternative transcripts generation mechanism in ADRA1A gene
• Evolutionary diversification of DYX1C1 transcripts via an HERV-H LTR integration event
• Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution

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