Absence of Androgen Receptors in the Prostatic Glandular Epithelium Derived from Testicular Feminization Mutant (Tfm) Mice : Developmental Biology

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Urogenital sinus epithelium from male embryos of Tfm androgen receptor defective mice was combined with urogenital sinus mesenchyme from normal rat embryos and the recombinates were grown underneath the kidney capsule of male nude mice. The Tfm epithelium formed prostatic buds which developed into fully formed glands. A few recombinates also formed seminal vesicles and coagulating glands. A study of androgen receptors by steroid autoradiography showed that labelling was absent in the epithelium but present in the mesenchyme surrounding the epithelium. In the control recombinates in which epithelium from normal wild type mice was combined with the rat mesenchyme both epithelium and mesenchyme were androgen-labelled. A study of the fine structure of the Tfm epithelium and its enzyme activity showed that both approximate those seen in the control epithelium. The results suggest that epithelial androgen may not be required for the cytodifferentiation of the epithelium and that both bud formation and cytodifferentiation are induced by the androgen activated mesenchyme. The possibility that androgens are necessary for epithelial cell proliferation and the synthesis of specific prostatic proteins, is discussed.
社団法人日本動物学会の論文
1988-10-15

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