Glandular Epithelium Induced from Urinary Bladder Epithelium of the Adult Rat Does Not Show Full Prostatic Cytodifferentiation : Developmental Biology

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Urinary bladder epithelium of the adult rat formed prostate-like glands, when combined with fetal urogenital sinus mesenchyme in culture and grafted beneath the renal capsule of male rat hosts. With the progression of the gland formation, the bladder epithelium lost its alkaline phosphatase activity and antigenicity against anti-functional bladder epithelium-antiserum. Like the normal prostate, the induced epithelium expressed acid phosphatase, nonspecific esterase and antigenicity against anti-human prostatic acid phosphatase-antiserum, but hardly expressed androgen receptors nor an antigen against anti-4-week prostate epithelium-antiserum. The SDS-PAGE patterns of total proteins in the induced glandular epithelium and in the normal epithelia of the urinary bladder and prostate revealed that the induced glandular epithelium loses some bands identified in the bladder epithelium and comes to express other bands similar to but not identical with those of the normal prostatic epithelium, suggesting that the induced gland does not differentiate as completely as the normal prostate, and this result is linked with extremely reduced androgen receptors in the induced epithelium.
社団法人日本動物学会の論文
1988-04-15