慢性骨髄性白血病患者におけるG群染色体の短腕欠失とその家系調査
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概要
- 論文の詳細を見る
The short arm deletion occurring in one of the G group chromosomes was observed in cells from leucocyte and bone marrow cultures of a patient with chronic myelogenous leukemia. Chromosomes were examined 5 times during a period from 11/2/67 to 6/17/68 in 3-day-old leucocyte cultures with and without PHA, and/or in bone marrow cells both directly and after cultivation without PHA for 3 days. In total of 211 metaphases, chromosomes were observed and 33 cells out of them were karyotyped. The short arm deleted chromosome was observed in all cells under study. Cells from skin cultures showed also the same chromosomal abnormality. Familial survey revealed that 3 siblings were carrier and 2 siblings were normal. It seems very probable that the short arm deletion of a G group chromosome is not always associated with leukemia. DNA replication pattern was studied autoradiographically. The short arm deleted chromosome replicated its DNA later than the other G group chromosomes. In the course of the blastic crisis, endoreduplication of the chromosomes was observed in about three percent mitoses of both leucocyte and bone marrow specimens.
- 社団法人日本動物学会の論文
- 1968-10-15
著者
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小原 良孝
弘前大学農学生命科学部生物機能科学教室
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小原 良孝
北海道大学理学部動物学教室
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Obara Yoshitaka
Dept. Biol. Fac. Sci. Hirosaki Univ.
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Obara Yoshitaka
Department Of Biology Faculty Of Science Hirosaki University
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