Glutamate Substitution for Glutamine at Position 5 or 6 Reduces Somatostatin Action in the Eel Intestine
スポンサーリンク
概要
- 論文の詳細を見る
Isolating a new somatostatin-like peptide from eel gut, the active residues to potentiate somatostatin action in the eel intestine were determined. In the newly-isolated peptide, the 5th or 6th Gln of the eel somatostatin (eSS-25II) was replaced with Glu. Although this peptide also enhanced the short-circuit current (I_<sc>) across the intestine of the seawater eel, higher concentrations (approximately 30 fold) were required to obtain the same effects as eSS-25II. Since the I_<sc> is due to active Cl^- transport, this indicates that a structure formed by Gln-Gln residues at position 5 and 6 potentiates the somatostatin action to enhance ion and water transport across the intestine of the eel.
- 社団法人日本動物学会の論文
- 1994-06-15
著者
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Uesaka Toshihiro
Laboratory Of Physiology Faculty Of Integrated Arts And Sciences Hiroshima University
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Uesaka Toshihiro
Laboratory For Neuronal Differentiation And Regeneration Riken Center For Developmental Biology
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YANO Keiichi
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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YAMASAKI Motoo
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Ando Masaaki
Laboratory of Physiology, Faculty of Integrated Arts and Sciences, Hiroshima University
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Yano K
Kyowa Hakko Co. Ltd. Tokyo
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Yano Keiichi
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ando M
Laboratory Of Integrative Physiology Faculty Of Integrated Arts And Sciences Hiroshima University
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Yamasaki Motoo
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd
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Uesaka T
Hiroshima Univ. Hiroshima
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Ando Masaaki
Laboratory Of Integrative Physiology Faculty Of Integrated Arts And Sciences Hiroshima University
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