Imidazoline Receptor Contributes to Ion and Water Transport across the Intestine of the Eel Acclimated to Sea Water(Physiology)
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概要
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Guanabenz, an I_2-imidazoline-related compound with high affinity for intestinal membrane of the eel (Kim et al., 1998), enhanced the transepithelial potential difference (PD) and short-circuit current (Isc) from serosa to mucosa after pretreatment with isobutylmethylxanthine (IBMX), serotonin (5-HT) and methacholine (MCh). The mucosal effect of guanabenz was not mimicked by adrenaline, indicating that the mucosal guanabenz binding site is not adrenoceptors. The mucosal guanabenz enhanced the Isc in a concentration-dependent manner. Similar enhancement in the Isc was also obtained after addition of other imidazoline derivatives such as ST93, clonidine, ST91, naphazoline and UK14,304 into the mucosal fluid. On the other hand, the effect of guanabenz was completely blocked by mucosal RX821002 or efaroxan, another imidazoline derivatives. Since some imidazoline derivatives act as agonists and others as antagonist, there must exist imidazoline receptor on the mucosal side of the eel intestine. Accompanied by an increase in the PD, NaCI and water absorption across the intestine was also enhanced by mucosal guanabenz. To search for endogenous ligands for the imidazoline receptor, luminal fluid in the intestine of the seawater eels was collected. However, most luminal fluid was ineffective. Only one among 10 samples showed guanabenz-like activity, suggesting that the endogenous ligands is secreted into the lumen under restricted condition alone.
- 社団法人日本動物学会の論文
- 2000-04-10
著者
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Takase Ichiro
Laboratory Of Physiology Faculty Of Integrated Arts And Sciences Hiroshima University
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Kim H
Hiroshima Univ. Hiroshima Jpn
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Kim Hung
Laboratory Of Physiology Faculty Of Integrated Arts And Sciences Hiroshima University
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Kawahara A
Hiroshima Univ. Higashi‐hiroshima Jpn
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Ando Masaaki
Laboratory of Physiology, Faculty of Integrated Arts and Sciences, Hiroshima University
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Kawahara Akira
Laboratory of Physiology, Faculty of Integrated Arts and Sciences, Hiroshima University
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Ando M
Laboratory Of Integrative Physiology Faculty Of Integrated Arts And Sciences Hiroshima University
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Ando Masaaki
Laboratory Of Integrative Physiology Faculty Of Integrated Arts And Sciences Hiroshima University
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