Effects of Inhibin on Rat Gonadal Differentiation and Development In Vitro
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概要
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Previously we examined that inhibin-α subunit, transforming growth factor-β_1 (TGF-β_1) and epidermal growth factor (EGF) were expressed in sex-, cell- and stage-specific manners in perinatal rat gonads. To clarify effects of these growth factors on the rat gonadal differentiation and development, indifferent gonadal primordia with mesonephric tubules on gestational day 13 were cultured in vitro for 4 days in serumfree CMRL-1066 medium with inhibin, TGF-β_1, EGF, anti-sera against these growth factors, testosterone or estradiol-17β, and then morphologically examined with reference to seminiferous tubule formation, germ cell division, Wolffian and Mullerian duct development. In male gonads, anti-inhibin-α serum suppressed the seminiferous tubule formation but inhibin, TGF-β_1, EGF or steroid hormones did not affect on the tubule formation, germ cell proliferation nor gonoduct development. Seminiferous tubules in male gonads cultured in the medium containing anti-inhibin-α serum were incomplete and irregular in shape. On the other hand, in female gonads, inhibin suppressed the germ cell division and anti-inhibin-(x serum led to the necrosis of germ cells, but other factors affected to neither sex cord formation nor germ cell division. Testosterone and estradiol-17_β stimulated female Wolffian and Mullerian duct development, respectively. These results indicate that inhibin induces the seminiferous tubule formation and suppresses the female germ cell division in developing rat gonads in vitro.
- 1996-06-15
著者
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Koike Satoshi
Department Of Mathematics Kyoto University
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Noumura Tetsuo
Department Of Biology Tokyo Metropolitan Institute Of Gerontology
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Koike Satoshi
Department Of Regulation Biology Faculty Of Science Saitama University:drug Safety Research Tsukuba
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Koike Satoshi
Department Of Mathematics Hyogo University Of Teacher Education
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