慢性炎症性脱髄性ポリニューロパチー

概要

論文の詳細を見る
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic disorder of the peripheral nervous system, and an immune-mediated mechanism is though to be the common underlying pathogenesis. There have been many reports of beneficial results from apheresis for CIDP. This improvement is associated with restoration of cunduction, which might be due either to remyelination or the removal of factors which impair conduction or remyelination. Two large, open, randomised and controlled trials have demonstrated the therapeutic effect of plasma exchange (PE), and the value of PE has been established for CIDP. The effectiveness of aphereiss differes according to individual cases. The cundtions of papproximately 60 % of the patients with CIDP improve with apheresis, but some groups of CIDP patients require long-term apheresis for the maintenance of remission. The different responsiveness suggests heterogeneity in the immuno-pathogenesis of CIDP. In Japan, double-filtration plasmapheresis (DFPP) and immunoadsorption plasmapheresis (IAPP) have been widely applied for CIDP. We hope that a controlled trial on the effect of apheresis (DFPP, IAPP) will be considered for CIDP in Japan, and that new therapwutic strategies will be developed with the improved understading of immunopathogenesis.
日本アフェレシス学会の論文
1999-06-30