乾燥ビール酵母投与のマウス腸管免疫系およびコラーゲン誘導関節炎に与える影響

概要

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DBA / 1J mice were fed on either a control or brewer's yeast(BY)diet for 4 months to study the effect of a BY diet on the immune system.In the first experiment, the effect of a BY diet on the intestinal immune system was investigated by immuno-histological observation.The number of B cells in the intestines was decreased in the BY group.In the second experiment, the effect of a BY diet on murine type II collagen-induced arthritis(CIA)was analyzed.The mice were immunized with type II collagen (CII)in Freund's complete adjuvant to induce arthritis.Tolerance was induced by orally administering CII for 6 weeks.A pathological analysis of joint inflammation showed that arthritis was suppressed by feeding BY in comparison with the control mice.Oral tolerance may thus have been influenced by feeding BY.These results suggest that BY may not only influence the intestinal immune system, but also suppress CIA.
社団法人日本家政学会の論文
2000-06-15