末梢血幹細胞動員および採取方法の発達

概要

論文の詳細を見る
Autologous peripheral blood cell transplantation (PBSCT) has been established as a procedure for hematopoietic stem cell rescue after marrow ablative chemoradiation therapy for patients with high-risk malignant diseases. To make a strategy for cancer treatment combined with PBSCT, the establishment of effective mobilization and harvesting protocol will be a key factor, and it must be updated according to the development of drugs or medical devices. We showed here that PBSC mobilization by G-CSF alone, even in pretreated patients whose PBSC were not effectively mobilized by chemotherapy plus G-CSF, can be induced as a practical method, and that this will make the clinical management of patients easier. Further, a newly developed special chamber for apheresis is quite effective for harvesting PBSCs from small children. These procedures can be applied for future gene therapy targeting pediatric patients and donors.
日本アフェレシス学会の論文
1998-02-28