自己免疫水疱症とアフェレシス : 落葉状天疱瘡(DFPP)

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The main treatment for pemphigus vulgaris (PV) and pemphigus foliaceus (PF) is oral corticosteroid administration. In some cases, however, a large amount of oral corticosteroid administration is not effective. And it is difficult to administer a large amount of oral corticosteroids for cases with complications, such as osteoporosis, diabetes mellitus, and digestive tract ulcer. Therefore some adjuvant therapies are used besides oral corticosteroids. The typical examples of adjuvant therapy are immunosuppressive reagents, DDS, and gold. In recent years, plasmapheresis has been proved to be an effective therapy. In Japan, plasmapheresis has been used to treat autoimmune bullous dicease since the first application for PV in l979, and many successful cases were reported. Double filtration plasmapheresis is the method that separates blood plasma from the blood corpuscle by the film filtration method, and it removes antibody selectively by running separated blood plasma through the secondary filter. This method has some advantages: 1) no use of other blood plasma such as FFP, and 2) no risk of infection and hepatitis. So DFPP is utilized more frequently than other methods in Japan. We tried to examine the effectiveness of DFPP for PF by analyzing with ELISA, indirect immumofluorescencse (IIF), and clinical manifestation. The one PF patient treated with DFPP was controled well after DFPP, but the other patient not treated with DFPP was not controlled well with a rise in pemphigus antibody titers shown by IIF and ELISA.
2000-10-31

自己免疫水疱症とアフェレシス : 落葉状天疱瘡(DFPP)

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